The demonstration of opioid receptors by radioligand binding and the discovery of their endogenous peptide ligands has provided a new class of compounds that can be used for the development of novel opioids. The number of potential receptor targets for such opioids has been expanded by the identification of multiple opioid receptor types The development of highly selective opioid peptides using the principles of conformational restriction permits the analysis of the structure‐activity requirements of each receptor type, and is facilitating the (...) elucidation of the functional properties of the different opioid receptors. (shrink)

Recognized as America's most original philosopher, Charles Sanders Peirce (1839-1914) was a practicing scientist, a logician, and a student of medieval philosophy and the history of science.

I argue that the specter haunting multiculturalism is incommensurability. In many discussions of multiculturalism there is a ‘picture’ that holds us captive — a picture of cultures, religious or ethnic groups that are self-contained and are radically incommensurable with each other. I explore and critique this concept of incommensurability. I trace the idea of incommensurability back to the discussion by Thomas Kuhn — and especially to the ways in which his views were received. Drawing on Gadamer’s understanding of hermeneutics, I (...) argue that the very idea of radical incommensurability is incoherent. This does not entail an abstract universalism but rather sensitivity to the ways in which all languages and cultures are in principle open to the real possibility of enlarging one’s vision and mutually understanding. (shrink)

With Slowing Metaphor Down: Elaborating Deliberate Metaphor Theory (henceforth SMD), Gerard J. Steen has given us a remarkable book, teeming with insights about metaphor use. The volume provides a...

Nietzsche announces his intentions to publish a “physiology of aesthetics”, namely a naturalistic explanation for how aesthetic judgements are grounded in the physiology of both the one experiencing the work, and the creator of it. But as well as the physiological reduction of aesthetic judgements, Nietzsche in many places across his oeuvre frames the apparatus of physiology, especially the prescriptive dimension of self-cultivation, in terms amenable to being treated as ‘aesthetic’. The first section will mount a (re-) defense of the (...) use of aestheticized language for discussing Nietzschean self-cultivation. The second section demonstrates an aesthetic evaluation of capacities that make possible the acquisition and removal of instinctual components, ultimately arguing for Nietzsche’s qualified indeterminism regarding the capacity for self-cultivation. The third section will assess the pres- ence of another aesthetic measure, this time in terms of envisaging one’s psycho-physiology by reference to an external spectacle. The final section discusses metaethical questions stemming from Nietzsche’s prescriptive language regarding the aestheticization of our physiology. (shrink)

"A fascinating and timely treatment of the objectivism versus relativism debates occurring in philosophy of science, literary theory, the social sciences, ...

Drawing freely and expertly from Continental and analytic traditions, Richard Bernstein examines a number of debates and controversies exemplified in the works of Gadamer, Habermas, Rorty, and Arendt. He argues that a "new conversation" is emerging about human rationality—a new understanding that emphasizes its practical character and has important ramifications both for thought and action.

Richard J. Bernstein is Vera List Professor of Philosophy at the New School for Social Research. The Essays: Philosophy, History, and Critique.